JuniCell
JuniCell is a Juniperus communis plant stem cell extract. Juniper stem cell line was established from young spring shoots that are especially rich in bioactive compounds but in nature are produced only for a limited period of time during season.
Stem cells of juniper contain high concentrations flavonoids, that contribute to specific biological activities.
JuniCell:
Promotes collagen production;
Protects skin keratinocytes from negative effects caused by ultraviolet light induced damages;
Alleviates skin inflammation caused by environmental stress;
Reduces accumulation of senescence markers and reverses cellular ageing.
Reduces melanin synthesis.
Activity
JuniCell promotes collagen production
Even at concentrations as low as 0.5% JuniCell promotes collagen expression in dermal fibroblasts. Collagen synthesis promoting activity contributes to the anti-ageing characteristics of JuniCell.
Antioxidative activity against UV and chemically induced damages
JuniCell protects skin keratinocytes from negative effects caused by ultraviolet light and pollution. It prevents free radical accumulation in skin cells. 0.5% (v/v) extract reduces UV and peroxide induced oxidative stress in skin cells (ROS quantified by flow cytometry).
Anti-inflammatory activity
JuniCell regulates expression of proinflammatory cytokines in skin keratinocytes and promotes expression of antioxidant enzyme superoxide disumutase 1 (SOD1). JuniCell shows this inflammation regulatory activity both in unstimulated keratinocytes as well as after stimulation with acne causing bacteria (Propionibacterium acnes).
JuniCell promotes 33% reduction of inflammatory cytokine IL-6 release from HaCaT keratinocytes stimulated by bacterial lysate.
Reduction of senescence markers
Reduces accumulation of senescence marker beta-galactosidase in dermal fibroblasts after UV-induced ageing (senescence marker quantified by flow cytometry).
Pigmenatation regulating activity
JuniCell acts on melanin synthesis in melanocytes. In B16-F10 melanocytes JuniCell reduced melanin synthesis by more than 23%.
Moreover it also has the ability to inhibit tyrosinase, the key enzyme involved in melanin synthesis.
Specification
INCI | Glycerin (and) water (and) Juniperus communis callus extract |
Key compounds | Citric acid, Quinic acid, Procyanidin B, Catechin |
Efficacy data – (in vitro) | |
Anti-ageing | Expression of collagen ↑ Expression of MMP-1 ↓ |
Anti-inflammatory | Proinflammatory cytokine expression ↓ SOD1 expression ↑ |
Antioxidant | ROS production ↓ NO scavenging activity ↑ |
Anti – allergic | Cell degranulation ↓ |
Technical Specification | |
Appearance | Yellow liquid |
Odour | Characteristic (mild) |
pH | 5.5 ± 0.5 at 25°C |
Solubility | Water soluble |
Total phenolic compounds | >800 μg/ml Gallic acid equivalents (Folin-Ciocalteu method) |
Recommended use level | 0.25%-0,75% |
Shelf life | 12 months |
Minimal order quantity | 0.5 kg |