DragonCell
DragonCell is an extract derived from Nothern dragonhead (Dracocephalum ruyshiana) stem cells. It contains high concentration of phenolic substances. Among them >60% are caffeic acid derivatives, including rosmarinic acid and chlorogenic acid. These are well known antioxidants with beneficial biological activities, including anti-inflammatory, anti-ageing and anti-rosacea.
DragonCell:
Boosts proliferation of dermal and epidermal cells reversing skin ageing processes;
Inhibits activity of collagen degrading enzymes;
Protects skin from photoaging and environmental stress induced skin damages, maintaining skin cell viability and proliferation rate;
Has angiogenesis regulating activity.
Activity
UV protective activity
DragonCell boosts capability of skin keratinocytes to resist UV light induced stress – after exposure to UVA/UVB viability of keratinocytes preincubated with 1%, DragonCell is 27% higher than control.
Anti-aging activity
Reduces expression and secretion of collagen degrading enzyme MMP-1 protecting from photoaging and environmental stress induced collagen breakdown (in vitro test in dermal fibroblasts).
Angiogenesis regulating activity
Rosacea and cuperose are conditions associated with inappropriate proliferation of endothelial cells, dilated blood vessels and changes in permeability of capillaries. DragonCell at concentrations 0.5% and 1% regulates proliferation of endothelial cells, formation and branching of capillaries. This makes DragonCell a valuable ingredient for anti-couperose and anti-rosacea applications.
Antioxidative activity
DragonCell at concentration 0,5% reduces ROS accumulation of 36% in HaCaT keratinocytes treated with UV (flow cytometry, n=3)
Anti-inflammatory activity
In vitro tests demonstrate efficacy in reducing the expression of interleukins that contribute to skin inflammation.
Specification
 | Raw material verified by ECOCERT Greenlife, conform to the COSMOS Standard |
|---|
INCI | Glycerin, water, Dracocephalum ruyschiana callus extract |
Key compounds | Rosmarinic acid, chlorogenic acid |
Efficacy data – (in vitro) | |
Anti-ageing | Skin cell proliferation ↑ Expression of collagen ↑ |
Anti-inflammatory | Expression of MMP-1 ↓ |
Antioxidant | Resistance from UV light induced stress ↑ |
Anti-Rosacea | Proliferation of endothelial cells, formation and branching of capillaries ↓ |
Technical Specification | |
Appearance | Brown liquid |
Odour | Characteristic (mild) |
pH | 6.5 ± 0.5 at 25°C |
Solubility | Water soluble |
Total phenolic compounds | >400 μg/ml Gallic acid equivalents (Folin-Ciocalteu method) |
Recommended use level | 0.5%-1% |
Shelf life | 12 months |
Minimal order quantity | 0.5 kg |